One Marie Curie Fellowship is now available to work on a 3 years PhD project in organic chemistry.
Project title and description
Design, synthesis and optimization of paramagnetic tags. Hit optimization.
The project will be focused on the synthesis and characterization of paramagnetic tags (complexes of lanthanides and nitroxyl radicals) to be conjugated to selected target proteins of high biomedical relevance and involved in pathologies that are considered important threats to human health such as cancer and parasitical diseases. In collaboration with the network, by employing nuclear magnetic resonance (NMR), these tags will be used to investigate the structural features of the target proteins in order to identify possible “hot spots” which are already present or that are induced upon protein-protein interaction. On the basis of the obtained structural results, inhibitor compounds able to bind to the “hot spots” will be identified and then optimized by the candidate employing methods of classical and multi-component reaction chemistry. The synthesized compounds will be tested and structure-activity relationships determined.
- Design and synthesize different kinds of paramagnetic tags in order to identify possible protein-protein interaction sites.
- On the basis of the obtained structural data, synthesize a library of inhibitor compounds, with the aim to optimize the structure of the hit inhibitors.
- Determine structure-activity relationships for the synthesized compounds.
The candidate is expected to interact and collaborate with researchers at Giotto Biotech, University of Florence and other AEGIS members.
- MSc degree in chemistry/organic chemistry/pharmaceutical sciences with a solid background in organic chemistry.
- Organic chemistry skills, particularly in the fields of coordination chemistry and/or radicals chemistry are a benefit, as well as NMR/HPLC/MS skills.
- Curiosity, willingness to learn and resourcefulness.
- Giotto Biotech is a start-up and spin-off of the University of Florence with a consolidated expertise in protein production and characterization, organic chemistry, metabolomics and has a full access to state of the art NMR instruments and laboratory facilities. The candidate will join a dynamic group of young researchers with skills that range from biotech, to NMR, to organic synthesis.
- The doctorate can be in Chemistry or Structural Biology, also taking into account the candidate preference.
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