Metabolomics services

For the biomedical, pharmaceutical, agro-food and probiotic sectors

NMR-based metabolomics

Pairing the power of nuclear magnetic resonance (NMR) with the science of metabolomics to provide you with state-of-the-art services for your key applications

Giotto Biotech, in collaboration with the Magnetic Resonance Center (CERM) at the University of Florence, is in a unique position to provide you with metabolomics services thanks to access to top-of-the-line instrumentation (including a fully robotized 600 MHz NMR machine for high volumes, a 600 MHz HR-MAS, and an 850 MHz solid-state machine for metabolomics on tissue extracts).

Some examples of the fields of application

  • Biomedical: metabolomic profiling of biological fluids (breath condensate, expectorate, sweat, urine, blood, serum), disease fingerprinting.
  • Pharmaceutical: prediction of drug toxicity, analysis of mechanism of action and side effects.
  • Agro-food: analyses of food products (fruits, vegetables, dairy products, olive oil, meat and fish, etc.).
  • Probiotic: metabolomics of probiotic products for their characterization.

Advantages of metabolomics by NMR

As compared to metabolomics by mass spectrometry, metabolomics by NMR:

  • is more accurate (though metabolomics by mass spectrometry is more sensitive);
  • does not require the destruction of samples;
  • involves easier sample preparation;
  • is faster.

Services

  • NMR screening and metabolomics of biological fluids, tissues and food products.
  • Metabolomic profiling and disease fingerprinting.
  • Biomarker discovery.
  • Drug studies (toxicity, mechanism of action, side effects).
  • Metabolomic statistical analysis service.

Instrumentation

Bruker IVDr 600 MHz spectrometer (Bruker BioSpin) operating at 600.13 MHz proton Larmor frequency, equipped with a 5 mm PATXI H/C/N with 2H-decoupling probe including a z axis gradient coil, an automatic tuning-matching (ATM) and an automatic refrigerated sample changer (SampleJet). An additional 600 MHz spectrometer is equipped with an HR-MAS probe for the metabolomic investigation of intact tissues and cells.

Contact us for further information

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Via Madonna del Piano, 6
50019 Sesto Fiorentino (FI), Italy
Tel. +39 055 457 4258
Fax +39 055 457 4925
E-mail: info@giottobiotech.com
VAT number: IT06188160482

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