The international conference Tailoring RNA binding proteins and RNA targeting will be held in Valencia on 14th and 15th September 2022. The Conference intends to bring together experts in the field that cover the broad scope of RNAct, from RNA binding proteins to RNA and back.

The conferrence aims to be a platform for high-level discussions involving academic experts and scientists from the biotech and pharma industries, covering the interactions between RBPs and RNA, the (re-)design of RBPs, the mechanisms of RBP-mediated post-transcriptional regulation, and the industrial application of RNA targeting/binding, including the targeting of RNA/RBPs by small molecules, in fields such as bioanalytics and synthetic biology.

CALL FOR ABSTRACTS OPEN – The call for the international conference “Tailoring RNA binding proteins and RNA targeting” is now open for submissions. You can find more information at the following link: http://rnact.eu/FinalConference/#abstracts

Joel Roca Martínez and Luca Sperotto visited Giotto Biotech laoratories in these days. They worked toghether with Anna Pérez i Ràfols, our PhD student, on RNAct project supported by Prof. Marco Fragai and Tommaso Martelli, PhD. Joel and Luca come respectvely from Vrije Universiteit (Brussel) and Helmholtz Zentrum (München).

Thanks to Innovative Training Networks Marie Curie that offers the possibility to train a new generation of creative, entrepreneurial and innovative early-stage researchers!

EC funded Glytunes proposal (H2020-MSCA-ITN-2020 call) to create a multidisciplinary training network for the bioinspired development of glycomimetics tuning the Siglec-Sialoglycan axis. The project GLYTUNES involves 7 academic partners and 4 companies (SMEs) from 7 European countries, combining world-class expertise in carbohydrate chemical and structural biology, drug design and computational chemistry, synthetic and medicinal chemistry, biophysics, biochemistry, glycoimmunology and molecular and medical microbiology.

Our partners in the project are Università degli Studi di Napoli Federico II, Quadram Institute Bioscience, Asociacion Centro de Investigacion cooperativa en biociencias, Stichting VUMC, Università degli Studi di Firenze, Centre National de la Recherche Scientifique (CNRS), Stichting Katholieke Universiteit, Atlas Molecular Pharma, Iceni Diagnostics, Glycouniverse

The first RNAct meeting was held in Brussels. Tommaso Martelli and Marco Fragai, as Giotto Biotech reference people for the network, met with the other partners to start the project (Vrije Universiteit Brussel, Centre National de la Recherche Scientifique, Helmholtz Zentrum Muenchen, Consejo Superior de Investigaciones Cientificas, Dynamic Biosensors GmbH, Ridgeview Instruments AB).

If you want to participate in our RNAct training network, you can apply for one of the open positions until March 15, 2019.

More information on the project can be found at http://rnact.eu
Applications must be submitted online at https://tinyurl.com/rnact-eu

“RNAct” – Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics

Giotto Biotech will start a new H2020-MSCA-ITN-2018 project on the 1st of January 2019. This new project will involve a large group of researchers from CNRS (FR), HMGU (DE), CSIC (SP), Dynamic Biosensors GMBH and Ridgeview Instruments AB (SE), UAB “Spronk NMR Consultancy” (LT), Universite de Liege (BE), Universite de Lorraine (FR), Uppsala Universitet (SE),  Università degli Studi di Firenze (IT), Universitat Politecnica de Valencia (ES), Technische Universitaet Muenchen (DE).

RNAct will create an integrated and multidisciplinary training and research programme for 10 broadly employable ESRs with versatile computational and experimental skills.

The RNAct research aim is the design of novel RNA recognition motif (RRM) proteins for exploitation in synthetic biology and bio-analytics. This is achieved through a design cycle that starts with computational approaches at the sequence and structure levels of proteins and RNA, in order to select amino acid positions and mutations for large-scale phage display experiments with RNA screening. Viable RRMs will be further investigated at the atomic level with integrative structural biology approaches, and will be applied in synthetic biology, to posttranscriptionally regulate fatty acid processing via RRMs, and in bio-analytics, to detect RNA in-cell and design RNA biochips.

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