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- 30% discount on all our NMR solution and SS standard – Use the promo code: Christmas2018
- 15% discount on fMLF – Use the promo code: Christmas2018fmlf
- 5% discount on SpiNpack – Use the promo code: Christmas2018spn
Maxime Denis, Giotto Biotech’s PhD student, presented his reasearch progress on “Design and optimization of paramagnetic tags for NMR”. His presentation was held in Paris at 5th AEGIS Training school.
This morning, Leonardo Tenori, member of Giotto Biotech Board of Director, spoke about Metabolomics based on NMR.
It was a great opportunity to illustrate to participants of Toscana Tech how Metabolomics based on NMR works and to offer some details about fields of application. Some examples of the fields of application are:
- Biomedical: metabolomic profiling of biological fluids (breath condensate, expectorate, sweat, urine, blood, serum), disease fingerprinting.
- Pharmaceutical: prediction of drug toxicity, analysis of mechanism of action and side effects.
- Agro-food: analyses of food products (fruits, vegetables, dairy products, olive oil, meat and fish, etc.).
- Probiotic: metabolomics of probiotic products for their characterization.
Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of the ‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites are chemical entities, small organic molecules or inorganic ions. Therefore, their proper identification and quantitation in complex biological matrices requires a solid chemical ground. With respect to e.g. DNA, metabolites are much more prone to oxidation or enzymatic degradation: we can reconstruct large parts of a mammoth’s genome from a small specimen, but we are unable to do the same with its metabolome, which was probably largely degraded a few hours after the animal’s death. Thus, we need standard operating procedures, good chemical skills in sample preparation for storage and subsequent analysis, accurate analytical procedures, a broad knowledge of chemometrics and advanced statistical tools, and a good knowledge of at least one of the two metabolomics techniques, MS or NMR. All these skills are traditionally cultivated by chemists. Here we focus on metabolomics from the chemical standpoint, and restrict ourselves to NMR. From the analytical point of view NMR has pros and cons, but does provide a peculiar holistic perspective that may speak for its future adoption as a population‐wide health screening technique.